01 -
Preheat oven to 425°F (218°C). Line a large baking sheet with parchment paper or foil.
02 -
Spray a 6-quart (or larger) slow cooker with non-stick cooking spray.
03 -
Trim excess fat from brisket and rinse under cold water. Pat dry thoroughly. If necessary, cut brisket in half to fit into the slow cooker.
04 -
In a medium bowl, combine paprika, brown sugar, chili powder, garlic powder, salt, onion powder, chipotle powder, black pepper, thyme, and cayenne pepper. Remove 1 tablespoon for barbecue sauce.
05 -
Rub remaining spice mixture evenly over all sides of the brisket. Place brisket on prepared baking sheet. Let stand 30 minutes at room temperature or refrigerate up to 24 hours if desired. Bake uncovered for 30 minutes to sear.
06 -
In a bowl, whisk ketchup, molasses, brown sugar, blackberry preserves, apple cider vinegar, reserved spice rub, and liquid smoke. Remove 1/2 cup barbecue sauce.
07 -
Add 1/2 cup barbecue sauce, water, Worcestershire sauce, soy sauce, and beef bouillon to the slow cooker. Whisk to combine.
08 -
Using tongs, transfer seared brisket into the slow cooker, nestling the meat into the liquid. Cover and cook on LOW for 8 to 10 hours, flipping the brisket halfway through, until fork-tender.
09 -
Preheat broiler. Transfer brisket to a foil-lined baking sheet. Brush generously with barbecue sauce. Broil for 5 to 10 minutes until surface is caramelized and slightly charred.
10 -
Warm remaining barbecue sauce in the microwave or on the stovetop until hot.
11 -
Brush brisket again with barbecue sauce. Slice across the grain or chop as desired. Serve drizzled with sauce or on sandwiches.
12 -
For advance preparation, cool brisket in its juices in the slow cooker insert, refrigerate, skim off fat, then rewarm on LOW for 1 to 2 hours. Finish with caramelization and serving steps.