Cattle Drive Casserole Layers

Featured in Satisfying Main Courses.

This layered casserole pays homage to classic Western flavors, pairing tender ground beef sautéed with red bell pepper and onion, all seasoned with taco spice. The base uses a biscuit dough pressed and pre-baked for extra heartiness, while a creamy mixture of sour cream, mayo, green chiles, and cheddar melts into every bite. Alternating flavors come from salsa and a cheesy finish. Enjoy hot from the oven, bubbly and golden, offering a slice of nostalgia that’s filling, festive, and sure to please a hungry crowd.

Barbara Chef
Updated on Fri, 18 Jul 2025 20:53:04 GMT
A slice of lasagna with cheese and herbs. Pin it
A slice of lasagna with cheese and herbs. | gracefulflavors.com

Cattle Drive Casserole is a hearty layered bake inspired by rustic cowboy flavors and Tex-Mex comfort food. You get a savory biscuit base topped with seasoned beef and a creamy cheesy finish that always brings folks back for seconds. When I need to please a hungry crowd or want leftovers that taste even better the next day this is my go to dish.

First time I made this my family cleared the pan and begged for more. It quickly became a Saturday night favorite at our table.

Ingredients

  • Lean ground beef: for rich savory flavor and satisfying protein tip choose beef with minimal visible fat for best texture
  • Red bell pepper: for a pop of color and sweetness look for one that feels heavy and firm
  • Yellow onion: adds depth and aromatic base pick one with dry papery skin
  • Taco seasoning: infuses the beef with Tex Mex spices go for a reputable brand with bold flavor
  • Biscuit mix: makes a fluffy crust layer use a trusted mix like Bisquick for consistency
  • Water: brings the biscuit dough together use cold water so dough is easier to handle
  • Cooking spray: keeps the base from sticking
  • Sour cream: for tang and creamy balance full fat yields best texture
  • Mayonnaise: adds richness and smoothness choose a mayo with a clean flavor
  • Diced green chiles: warm and slightly smoky flavor drain well to avoid watery filling
  • Cheddar cheese fiesta blend: gives melty goodness and punchy taste fresh shredding melts best
  • Garlic powder: amps up the savory notes
  • Salsa: brightens things up and ties the Tex Mex flavors together look for fresh style jarred salsa if available

Step by Step Instructions

Preheat the Oven:
Set the oven to three hundred fifty degrees Fahrenheit to get a head start on perfect baking texture
Cook the Ground Beef:
Heat a large skillet over medium high cook the ground beef by breaking it up with a spoon letting it brown fully and become crumbly for best flavor and texture drain any grease for a less greasy casserole
Prepare the Biscuit Dough:
Mix biscuit mix and cold water in a medium bowl blend with hands for a cohesive dough spray the baking dish to prevent sticking then gently press the dough into an even layer covering the bottom and slightly up the sides partially bake until the dough looks just set and lightly golden to lay a sturdy base
Cook Vegetables:
Add chopped onion and red bell pepper to the beef mixture allow everything to soften for about four minutes so the veggies release sweetness and aroma stir in taco seasoning thoroughly then take the pan off heat
Assemble the Layers:
Evenly distribute the seasoned beef and veggie layer onto the prebaked biscuit crust smooth it out to cover every corner for even flavor in each bite
Make the Sour Cream Layer:
In a clean bowl mix sour cream mayonnaise drained green chiles garlic powder and most of the shredded cheese blend until completely smooth then gently spread this creamy layer over the beef mixture without tearing the layers below
Top with Salsa and Cheese:
Drop small spoonfuls of salsa right on top of the creamy layer letting the juices seep in finish with a handful of remaining shredded cheese spread evenly for a golden bubbly topping
Bake:
Return the casserole to the oven uncovered bake until hot throughout and the top is bubbling with golden cheese usually about thirty minutes let it stand a few minutes before serving so it holds together for perfect slices
A slice of pizza with cheese and sauce. Pin it
A slice of pizza with cheese and sauce. | gracefulflavors.com

I always crave the cheesy golden crust the best part for scooping up the rich beef and creamy layers it reminds me of family movie nights when this casserole was always in the center of the table

Storage Tips

Store cooled leftovers in a tightly covered container in the refrigerator for up to four days. This casserole also freezes nicely. Slice individual portions and wrap in foil or place in airtight containers. Reheat gently covered in the oven or in the microwave for easy lunches.

Ingredient Substitutions

Swap Monterey Jack or pepper jack for some of the cheddar to add variety in flavor or spice. Ground turkey works just as well as beef and light sour cream keeps things tangy but lighter. For a gluten free version use a biscuit mix designed for gluten sensitivities and double check your taco seasoning ingredients.

Serving Suggestions

Serve this casserole with a crisp green salad tossed in lime vinaigrette or a side of rice and beans for extra heartiness. Add sliced avocado or a dollop of extra sour cream on top. Tortilla chips make a crunchy vehicle for scooping up every bit.

A slice of lasagna with cheese and herbs. Pin it
A slice of lasagna with cheese and herbs. | gracefulflavors.com

Cultural Context

This dish is inspired by cowboy campfire meals with roots in layered casseroles of the American Southwest. The biscuit base hints at classic Southern comfort food while the seasoned beef and peppers echo Tex Mex kitchen traditions passed down through generations.

Frequently Asked Questions

→ What kind of ground beef works best?

Use lean ground beef for less excess fat. An 80/20 or 85/15 blend cooks up flavorful and moist without much grease.

→ Can I use a different cheese blend?

Yes, cheddar or a fiesta blend works well, but Monterey Jack, pepper jack, or a Mexican cheese blend can also be used.

→ Is it possible to make ahead?

Assemble the layers up to a day in advance, cover, and refrigerate. Bake just before serving for best results.

→ Can this be frozen after baking?

Yes, let it cool, wrap tightly, and freeze. Thaw in the refrigerator before reheating for even warming and texture.

→ What sides pair well with this dish?

Serve with a simple green salad, steamed vegetables, or Mexican rice for a complete meal that balances the hearty layers.

Cattle Drive Casserole Layers

Savor bold layers of seasoned ground beef, tangy salsa, and creamy cheese on a golden biscuit crust.

Prep Time
20 Minutes
Cook Time
40 Minutes
Total Time
60 Minutes
By: Barbara

Category: Hearty Mains

Difficulty: Intermediate

Cuisine: Tex-Mex

Yield: 8 Servings (One 9 x 13 inch casserole)

Dietary: ~

Ingredients

→ For the Casserole Base

01 2 1/2 cups biscuit mix (such as Bisquick)
02 1 cup water
03 Cooking spray

→ For the Filling and Topping

04 1.5 pounds lean ground beef
05 1 red bell pepper, seeded and chopped
06 1 yellow onion, chopped
07 1 ounce taco seasoning mix
08 1/2 cup sour cream
09 1/2 cup mayonnaise
10 4 ounces diced green chiles, drained
11 1 1/2 cups cheddar cheese, fiesta blend, shredded, divided
12 1 teaspoon garlic powder
13 1/2 cup mild salsa

Instructions

Step 01

Set oven to 350°F (177°C) and allow to preheat while preparing ingredients.

Step 02

Heat a large skillet over medium-high heat. Add ground beef and break apart with a spoon. Cook until browned and no longer pink, stirring occasionally. Drain excess fat.

Step 03

In a medium mixing bowl, combine biscuit mix with water. Blend by hand until dough forms. Spray a 9 x 13 inch casserole dish with cooking spray. Press biscuit dough evenly into dish, spreading to edges. Bake in preheated oven for 5–8 minutes, until dough is just set and lightly golden. Remove and set aside.

Step 04

To the skillet with cooked beef, add chopped onion and red bell pepper. Stir and sauté for about 4 minutes. Add taco seasoning, mix well, then remove skillet from heat.

Step 05

Evenly distribute the cooked beef and vegetable mixture over the pre-baked biscuit crust in the casserole dish.

Step 06

In a clean medium bowl, combine sour cream, mayonnaise, drained green chiles, 3/4 cup shredded cheddar cheese, and garlic powder. Mix until smooth.

Step 07

Carefully spread the sour cream mixture over the beef layer, covering evenly.

Step 08

Drop spoonfuls of salsa over the sour cream layer without spreading. Sprinkle the remaining 3/4 cup shredded cheddar cheese evenly on top.

Step 09

Place the assembled casserole back in the oven, uncovered, and bake for 30 minutes or until the center is hot and the top is bubbly and golden.

Step 10

Allow casserole to rest for 10 minutes before slicing and serving.

Notes

  1. For a spicier flavor, substitute medium or hot salsa and add chopped jalapeños to the beef mixture.

Tools You'll Need

  • Large skillet
  • Medium mixing bowls
  • 9 x 13 inch casserole dish

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains milk and dairy ingredients (cheese, sour cream, mayonnaise)
  • Contains wheat (biscuit mix)
  • Contains eggs (mayonnaise, possibly biscuit mix)

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 483
  • Total Fat: 30 g
  • Total Carbohydrate: 29 g
  • Protein: 23 g