Mac and Cheese Meatloaf

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Mac and Cheese Meatloaf Casserole is the perfect combination of hearty and cheesy flavors. This dish layers a beef-packed meatloaf base with a creamy macaroni and cheese mixture, topped with a golden melted cheese crust. It's easy to make in steps—mix the ground beef with crackers and onion soup mix, bake it with a barbecue glaze, and finish by adding a rich macaroni layer. Garnish with customizable cheese blends to suit your tastes. Serve warm and enjoy this ultimate comfort food that's sure to please family and friends.

Barbara Chef
Updated on Mon, 05 May 2025 14:37:04 GMT
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This mac and cheese meatloaf casserole combines two comfort food classics into one incredible dish that satisfies even the pickiest eaters. The savory meatloaf base topped with creamy, cheesy macaroni creates a complete meal my family requests at least twice a month.

I first created this recipe when my children had friends over for dinner with vastly different food preferences. This casserole has since become our go to solution for pleasing everyone at the table while providing a hearty complete meal.

Ingredients

  • Lean ground beef: provides the substantial base and keeps the dish from becoming too greasy
  • Ritz Crackers: add a buttery flavor and perfect texture that breadcrumbs just cannot match
  • Lipton onion soup mix: brings complex seasoning without needing dozens of individual spices
  • Sweet Baby Rays BBQ sauce: creates that perfect tangy sweet glaze that caramelizes beautifully
  • Condensed cheddar cheese soup: ensures your mac and cheese turns out creamy every time
  • Shredded cheese blend: allows the perfect melty texture while offering depth of flavor

Step-by-Step Instructions

Prepare the Sauce Base:
Combine ketchup and barbecue sauce in a bowl until fully integrated. This sauce mixture does double duty first as part of the meat mixture and later creating that irresistible glaze on top of the meatloaf. The sweetness from the Brown Sugar BBQ sauce caramelizes beautifully during baking.
Create the Meatloaf Mixture:
Combine ground beef with crushed Ritz crackers until evenly distributed. Add onion soup mix which infuses the meat with savory flavor throughout. Mix in eggs and half cup of the sauce mixture using your hands until just combined but not overworked. The crackers maintain moisture while the eggs bind everything together perfectly.
Form and Bake Initial Layer:
Press the meat mixture firmly into your baking dish creating an even layer. Apply remaining sauce mixture across the top in a smooth layer. Initial baking for 30 minutes allows the meat to cook partially before adding the macaroni topping.
Prepare the Macaroni Mixture:
Cook macaroni just until al dente as it will continue cooking in the oven. Whisk milk and cheese soup together creating a smooth base. Add seasonings and gently fold in the cooked macaroni and half the cheese. This creates a velvety sauce that coats every noodle perfectly.
Assemble and Bake Final Dish:
Pour the macaroni mixture over the partially baked meatloaf creating a distinct second layer. Top with remaining cheese and return to oven. Watch for the cheese to become golden brown and bubbly around the edges which indicates it has reached perfection.
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Mac and Cheese Meatloaf Casserole Recipe | gracefulflavors.com

My kids always fight over the corner pieces where the cheese gets extra crispy and the sauce caramelizes. I started making this in two smaller pans instead of one large one just so everyone could have their favorite part.

Make Ahead Instructions

This casserole works beautifully as a prepare ahead meal. You can complete all steps up through adding the macaroni layer but before the final baking. Cover tightly with foil and refrigerate for up to 24 hours. When ready to serve allow the dish to sit at room temperature for 30 minutes then bake for 25 to 30 minutes until heated through and the cheese is bubbling.

Creative Variations

Try Italian style by using Italian seasoned ground beef or turkey adding a layer of marinara instead of BBQ sauce and using provolone and mozzarella cheeses. For a southwestern twist incorporate taco seasoning into the meat mixture substitute salsa for some of the sauce and use pepper jack cheese in your blend. These variations keep the same cooking method but transform the flavor profile completely.

Serving Suggestions

This hearty casserole pairs perfectly with simple green vegetables like roasted broccoli or a fresh garden salad with vinaigrette. The bright acidic notes from a side salad help balance the rich creamy elements of the casserole. For a truly decadent meal serve with buttery garlic bread to soak up any extra sauce.

Storage and Reheating

Store leftovers covered in the refrigerator for up to 4 days. For best reheating results cover with foil and warm in a 325°F oven for about 20 minutes until heated through. If using a microwave cover loosely and heat at 70% power checking every minute to prevent the pasta from becoming tough. The flavors actually develop overnight making this one of those rare dishes that tastes even better the next day.

Frequently Asked Questions

→ Can I prepare this casserole ahead of time?

Yes, you can assemble the layers ahead of time and keep it in the fridge. Bake it just before serving for best results.

→ What can I use as a substitute for Ritz Crackers?

Crushed saltine crackers, breadcrumbs, or gluten-free crackers work well as substitutes for Ritz Crackers.

→ How can I make this dish gluten-free?

Use gluten-free crackers, onion soup mix, and noodles to make this dish gluten-free.

→ Can I change the cheese blend in this casserole?

Absolutely! Feel free to use your favorite cheeses like Monterey Jack, Gouda, or Colby for a personalized flavor.

→ How do I store leftovers?

Store leftovers in an airtight container in the fridge for up to 3 days. Reheat in the oven or microwave before serving.

Mac and Cheese Meatloaf

Hearty meatloaf and cheesy macaroni layers combined for ultimate comfort food.

Prep Time
25 Minutes
Cook Time
50 Minutes
Total Time
75 Minutes
By: Barbara

Category: Hearty Mains

Difficulty: Intermediate

Cuisine: American

Yield: 8 Servings (1 casserole)

Dietary: ~

Ingredients

→ Sauces

01 1 cup ketchup
02 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce

→ Meatloaf base

03 2 lbs lean ground beef
04 30 Ritz Crackers, crushed
05 2 oz Lipton onion soup mix
06 2 eggs

→ Macaroni mixture

07 3 cups macaroni noodles
08 2 cups milk
09 10.5 oz condensed cheddar cheese soup
10 1 tsp salt
11 1 tsp pepper
12 1 tbsp garlic powder
13 1 tbsp onion powder
14 4 cups shredded mozzarella and cheddar cheese blend

Instructions

Step 01

Preheat the oven to 350°F (175°C). Grease a 9×13 inch baking dish.

Step 02

In a medium mixing bowl, combine the ketchup and barbecue sauce. Set aside.

Step 03

In a large mixing bowl, add the ground beef. Crush Ritz Crackers and add to the bowl. Add the Lipton onion soup mix and eggs, then pour in 1/2 cup of the ketchup and barbecue sauce mixture. Mix all ingredients together until fully combined.

Step 04

Press the mixture evenly into the prepared baking dish. Spread the remaining ketchup and barbecue sauce mixture on top. Bake for 30 minutes.

Step 05

Cook the macaroni noodles according to package directions, then drain.

Step 06

In a large bowl, whisk together milk and condensed cheddar cheese soup until smooth. Add salt, pepper, garlic powder, and onion powder. Stir in cooked macaroni and 2 cups of shredded cheese.

Step 07

Remove the meatloaf from the oven. Pour the macaroni mixture evenly on top. Sprinkle the remaining cheese over it. Bake for an additional 17-20 minutes, until the cheese is melted and starting to brown.

Step 08

Let the casserole sit for a few minutes before serving.

Notes

  1. Customize the cheese blend to your preference.
  2. For a gluten-free version, use gluten-free crackers, soup mix, and noodles.
  3. This dish can be prepared ahead of time and baked just before serving.

Tools You'll Need

  • 9×13 inch baking dish
  • Large mixing bowl
  • Medium mixing bowl
  • Whisk

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains dairy (cheese, milk)
  • Contains gluten (Ritz Crackers, soup mix, noodles)
  • Contains eggs

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 720.5
  • Total Fat: 41 g
  • Total Carbohydrate: 45 g
  • Protein: 38 g