Stuffed Catfish with Spinach, Shrimp, and Cheese

Featured in Satisfying Main Courses.

Fresh catfish fillets are carefully slit to create pockets and filled with a mixture of sautéed shrimp, wilted spinach, cream cheese, Parmesan, and a hint of garlic and lemon. Gently baked until flaky, this dish offers a creamy, savory bite with layers of fresh and rich flavors. The delicate balance of tender seafood, vibrant greens, and melted cheese makes it an inviting main course. Garnished with fresh herbs, it pairs beautifully with steamed vegetables or rice for a satisfying meal.

The preparation starts with quick sautéing to preserve the shrimp's tenderness and spinach's freshness. The filling melds smoothly with cream cheese and Parmesan, adding richness without overwhelming the natural flavors. Baking at 375°F ensures the catfish stays moist while fully cooking through. Finishing with lemon juice brightens the dish for a balanced taste experience that’s simple yet elegant enough for any evening.

Barbara Chef
Updated on Sat, 27 Dec 2025 03:39:21 GMT
A plate of shrimp and cheese. Pin it
A plate of shrimp and cheese. | gracefulflavors.com

This stuffed catfish recipe combines tender fresh catfish fillets with a rich filling of shrimp, spinach, and creamy cheeses. Baking the fish enfolds the flavorful mixture into a perfectly cooked main course that is both light and satisfying. This dish brings Southern-inspired comfort to your dinner table without feeling heavy.

I remember making this for a casual family dinner and everyone was surprised by how surprisingly elegant and flavorful the dish turned out. It quickly became one of my go-to recipes when I want something special but simple.

Ingredients

  • Fresh boneless catfish fillets choose firm, white fillets for mild flavor and easy stuffing
  • Small peeled shrimp chopped to blend in smoothly with the filling and cook evenly
  • Fresh spinach roughly chopped to brighten and add nutrition without overpowering
  • Cream cheese softened to create a creamy binder for the filling
  • Grated Parmesan cheese adds a savory depth quality Parmigiano Reggiano works beautifully
  • Garlic minced fresh garlic boosts aroma and base flavor
  • Lemon juice brightens the richness and balances the dish
  • Olive oil for sautéing and drizzling adds subtle fruitiness and helps cooking
  • Salt and black pepper essential for seasoning and enhancing all elements
  • Fresh parsley or dill chopped for a final fresh garnish that lifts the presentation and taste

Step-by-Step Instructions

Prepare the Filling:
Heat olive oil in a skillet over medium heat. Add minced garlic and cook until fragrant but not browned, about 1 to 2 minutes. Add fresh spinach and sauté until wilted, roughly 3 minutes. Toss in chopped shrimp and cook just until pink and tender, about 2 to 3 minutes. Remove the skillet from heat. Stir in softened cream cheese, grated Parmesan, lemon juice, salt, and black pepper until the mixture is smooth and fully combined. Set aside to cool slightly before stuffing.
Prepare the Catfish Fillets:
Pat the catfish fillets dry with paper towels for better browning and seasoning adherence. Lightly season both sides with salt and pepper. Carefully make a horizontal slit lengthwise through each fillet to create a pocket, taking care not to cut all the way through.
Stuff the Fillets:
Fill each catfish pocket generously with the shrimp and spinach mixture. If needed, secure the edges with toothpicks to keep the filling inside during baking.
Bake the Stuffed Catfish:
Preheat the oven to 375 degrees Fahrenheit (190 degrees Celsius). Lightly grease a baking dish or line with parchment paper. Place the stuffed fillets in the dish and drizzle with a bit of olive oil. Bake for 20 to 25 minutes until the fish is opaque and flakes easily with a fork.
Garnish and Serve:
Remove toothpicks gently. Drizzle additional lemon juice over the fillets and sprinkle chopped fresh parsley or dill on top for brightness. Serve immediately alongside steamed vegetables or rice for a complete meal.
A bowl of shrimp and cheese. Pin it
A bowl of shrimp and cheese. | gracefulflavors.com

Storage Tips

Store leftovers in an airtight container in the refrigerator for up to two days. Reheat gently in the oven at a low temperature to keep the fish moist and creamy. Avoid microwaving as it can dry out the delicate fillets.

Ingredient Substitutions

Replace Parmesan cheese with Pecorino Romano for a sharper, saltier edge or a mild mild white cheddar for a different but tasty twist. Use kale or Swiss chard instead of spinach if you want a heartier green. Canned cooked shrimp can work in a pinch but fresh shrimp adds the best texture.

Serving Suggestions

Pair the stuffed catfish with steamed green beans and roasted new potatoes for a balanced Southern-inspired meal. A crisp side salad with lemon vinaigrette complements the richness of the filling nicely. A light white wine such as Sauvignon Blanc or unoaked Chardonnay also pairs well with this dish.

Cultural Context

Catfish has a strong tradition in Southern US cooking, often fried or blackened. This stuffed version elevates the fish into something refined yet rooted in satisfying, bold flavors. Incorporating shrimp and greens reflects the coastal influences and the fresh seafood rich in that cuisine.

A bowl of food with shrimp and cheese. Pin it
A bowl of food with shrimp and cheese. | gracefulflavors.com

Frequently Asked Questions

→ What type of catfish is best for this dish?

Fresh, boneless catfish fillets work best to ensure tender, flaky results and easy preparation.

→ How can I tell when the stuffed catfish is fully cooked?

The fish is done when it becomes opaque and flakes easily with a fork, usually after 20-25 minutes of baking at 375°F.

→ Can other cheeses be used in place of Parmesan?

Yes, Pecorino Romano is a great substitute if you prefer a sharper, saltier flavor in the filling.

→ What is the best way to keep the filling inside the fish during baking?

Secure the stuffed pockets with toothpicks or kitchen twine to hold the filling in place while baking.

→ What sides complement this stuffed catfish dish?

Steamed vegetables, rice, or a light salad pair well to balance the rich, creamy flavors of the main dish.

→ How should the shrimp be cooked before stuffing?

Sauté the shrimp briefly just until pink and tender to avoid overcooking and maintain its delicate texture.

Stuffed Catfish with Shrimp

Baked catfish filled with shrimp, spinach, and creamy cheese for a delicious, wholesome meal.

Prep Time
15 Minutes
Cook Time
25 Minutes
Total Time
40 Minutes
By: Barbara

Category: Hearty Mains

Difficulty: Intermediate

Cuisine: Southern

Yield: 4 Servings (4 stuffed catfish fillets)

Dietary: Low-Carb, Gluten-Free

Ingredients

→ Catfish and Filling

01 4 fresh boneless catfish fillets
02 1 cup small peeled shrimp, chopped
03 2 cups fresh spinach, roughly chopped
04 4 oz cream cheese, softened
05 1/4 cup grated Parmesan cheese
06 2 cloves garlic, minced
07 1 tablespoon lemon juice
08 2 tablespoons olive oil
09 Salt, to taste
10 Black pepper, to taste
11 Fresh parsley or dill, chopped (for garnish)

Instructions

Step 01

Heat olive oil in a skillet over medium heat and sauté the minced garlic until fragrant. Add fresh spinach and cook until wilted. Toss in chopped shrimp and cook until pink and tender. Remove from heat and stir in cream cheese, Parmesan, lemon juice, salt, and pepper until smooth. Set aside to cool slightly.

Step 02

Pat catfish fillets dry and season with salt and pepper on both sides. Carefully create a horizontal pocket in each fillet without cutting through.

Step 03

Fill each catfish pocket generously with the shrimp-spinach-cheese mixture. Secure edges with toothpicks if needed to hold the filling.

Step 04

Preheat oven to 375°F (190°C). Place stuffed fillets on a greased baking dish or parchment-lined sheet. Drizzle olive oil over the top and bake for 20 to 25 minutes, until fish is opaque and flakes easily.

Step 05

Remove toothpicks, drizzle with additional lemon juice, and sprinkle chopped fresh herbs. Serve immediately with preferred sides.

Notes

  1. Use fresh catfish fillets for optimal flavor. Substitute Parmesan with Pecorino Romano for a sharper taste. Secure stuffing with kitchen twine as an alternative to toothpicks. Do not overcook shrimp to maintain tenderness.

Tools You'll Need

  • Skillet
  • Oven
  • Baking dish or sheet
  • Knife
  • Toothpicks or kitchen twine

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains shellfish, dairy

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 380
  • Total Fat: 23 g
  • Total Carbohydrate: 5 g
  • Protein: 36 g