John Wayne Beef Casserole

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This classic casserole features a savory base of browned, seasoned ground beef combined with diced tomatoes and optional onions. A biscuit dough crust forms a tender, golden foundation that bakes beautifully. Topped with a creamy mix of sour cream, mayonnaise, and sharp cheddar cheese, then finished with melted cheddar on top. Simple steps and pantry staples make this dish both satisfying and easy for any level of home cooking.

Barbara Chef
Updated on Sat, 20 Dec 2025 18:27:11 GMT
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A slice of lasagna on a plate. | gracefulflavors.com

John Wayne Casserole is the kind of comfort food that feels like a warm hug after a long day. It layers simple ingredients into a hearty meal that everyone will ask for again. This dish brings together familiar flavors with a creamy cheese topping and a biscuit crust that makes every bite satisfying.

I first made this casserole when I needed a quick but impressive meal. It quickly became a favorite around my house especially because the creamy layer makes it feel special with very little effort.

Ingredients

  • Ground beef: one pound fresh and lean to keep the casserole rich but not greasy
  • Taco seasoning: one packet introduced for a perfect blend of spice and flavor without extra work
  • Water: one cup allows the seasoning to meld with the beef and helps create a saucy base
  • Diced tomatoes with green chilies: one can ten ounces drained adds a subtle heat and acidity that brightens the dish
  • Chopped onion: half a cup optional but brings a natural sweetness and depth when cooked
  • Salt and pepper: to taste essential for balancing the flavors
  • Sour cream: half a cup gives the creamy top tanginess and smoothness
  • Mayonnaise: half a cup adds richness and keeps the topping moist
  • Shredded cheddar cheese: two cups total divided one cup mixed into the creamy layer and one cup sprinkled on top for melty cheese perfection
  • Refrigerated biscuit dough: one can eight-count this forms the soft crust that holds everything together

Step-by-Step Instructions

Prepare Your Kitchen:
Preheat the oven to 350 degrees Fahrenheit. Lightly grease a nine by thirteen-inch baking dish to prevent sticking. Warm a skillet over medium heat to start cooking the beef evenly.
Cook the Beef Layer:
Place the ground beef into the skillet and cook, stirring, until no pink remains. Drain off excess grease so the casserole isn’t oily. Sprinkle in the taco seasoning and pour the water over the beef. Stir and let simmer until most of the liquid disappears. Add the drained diced tomatoes with green chilies and the optional onions. Cook for another few minutes to blend flavors. Season with salt and pepper according to your taste.
Build the Biscuit Base:
Open the biscuit dough and press the pieces evenly across the bottom of the prepared dish. Overlap slightly as needed to form one uniform layer. This will bake into a tender and slightly crispy crust that supports the layers above.
Add the Layers:
Spoon the beef mixture carefully over the biscuit crust creating an even layer. In a separate bowl, combine sour cream, mayonnaise, and one cup of shredded cheddar cheese. Spread this creamy topping over the beef layer, then finish by sprinkling the last cup of cheddar cheese on top.
Bake to Perfection:
Place the casserole in the oven and bake for about 25 to 30 minutes. You want the cheese on top to be melted, bubbly, and lightly golden. The biscuit crust should be fully cooked and slightly golden on the edges. Remove from oven and let rest for five minutes before cutting. This helps keep the layers together nicely.
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A slice of lasagna on a white plate. | gracefulflavors.com

My favorite part is the biscuit crust. It makes this casserole feel more like a complete meal instead of just layers of beef and cheese. We often made this for game nights where it disappeared fast and the cheesy aroma always got everyone excited.

Storage Tips

Store leftovers in an airtight container and refrigerate for up to three days. Reheat gently in the oven to keep the biscuit crust from getting soggy. This casserole also freezes well if you want to make a big batch ahead and enjoy it later. Just thaw overnight in the fridge before reheating.

Ingredient Substitutions

Ground turkey or chicken can be swapped for beef to lighten up the dish. For a dairy-free option, try using plant-based sour cream and cheese alternatives. If you prefer less spice, omit the green chilies or replace taco seasoning with a mild blend of your choice.

Serving Suggestions

Serve with a simple green salad dressed with lime vinaigrette to cut through the richness. A side of sautéed vegetables like corn or green beans pairs nicely. For a fun family dinner, offer salsa or guacamole as toppings.

Cultural Context

John Wayne Casserole is a twist on classic Tex-Mex flavors with an easy American casserole style. It’s inspired by cowboy hearty meals that needed to be filling and made with whatever was on hand. The biscuit crust adds a Southern touch, making it familiar across many American kitchens.

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A white plate with a casserole on it. | gracefulflavors.com

Frequently Asked Questions

→ Can I use fresh tomatoes instead of canned?

Yes, fresh diced tomatoes can be used, but draining excess liquid helps prevent a soggy base and maintains the casserole's texture.

→ What can I substitute for the biscuit dough crust?

Pie crust or puff pastry can work as alternatives, but the biscuit dough provides a tender, slightly fluffy foundation unique to this dish.

→ Is it possible to add vegetables to this dish?

Absolutely, diced bell peppers or corn can be stirred into the beef mixture to add extra flavor and texture.

→ How do I prevent the creamy topping from separating during baking?

Mix sour cream, mayonnaise, and shredded cheddar thoroughly before spreading evenly. Bake at a moderate temperature to maintain smoothness.

→ Can I prepare this casserole ahead of time?

Yes, assemble the layers in advance and keep covered in the refrigerator. Bake fresh when ready to serve for best results.

John Wayne Beef Casserole

Layered ground beef, creamy cheddar topping, and biscuit crust combine for a warm, hearty casserole.

Prep Time
15 Minutes
Cook Time
30 Minutes
Total Time
45 Minutes
By: Barbara

Category: Hearty Mains

Difficulty: Easy

Cuisine: American

Yield: 8 Servings

Dietary: ~

Ingredients

→ Meat Layer

01 1 pound ground beef
02 1 packet taco seasoning
03 1 cup water
04 1 can (10 ounces) diced tomatoes with green chilies, drained
05 ½ cup chopped onion (optional)
06 Salt and pepper to taste

→ Creamy Layer

07 ½ cup sour cream
08 ½ cup mayonnaise
09 1 cup shredded cheddar cheese

→ Crust and Topping

10 1 can (8-count) refrigerated biscuit dough
11 1 cup shredded cheddar cheese

Instructions

Step 01

Preheat oven to 175°C (350°F). Grease a 23x33 cm (9x13-inch) baking dish and place it aside. Warm a skillet over medium heat.

Step 02

Brown ground beef in the skillet until fully cooked. Drain excess fat. Stir in taco seasoning and water, simmer until most liquid is absorbed. Add drained diced tomatoes with green chilies and chopped onion if using. Cook together for 2 minutes. Season with salt and pepper.

Step 03

Press biscuit dough evenly into the bottom of the prepared baking dish, overlapping pieces to create a solid layer forming the crust.

Step 04

Spread the beef mixture evenly over the biscuit crust. In a bowl, combine sour cream, mayonnaise, and 1 cup shredded cheddar cheese. Spread this creamy mixture evenly over the beef layer. Sprinkle remaining cheddar cheese on top.

Step 05

Bake in the preheated oven for 25 to 30 minutes until cheese is melted, bubbly, lightly browned, and biscuit crust is cooked through. Let rest for 5 minutes before slicing to allow layers to set.

Notes

  1. Letting the casserole rest after baking helps the layers hold together well when serving.

Tools You'll Need

  • Skillet
  • 9x13-inch baking dish
  • Mixing bowl

Allergy Information

Please check ingredients for potential allergens and consult a health professional if in doubt.
  • Contains dairy and gluten

Nutrition Facts (Per Serving)

It is important to consider this information as approximate and not to use it as definitive health advice.
  • Calories: 450
  • Total Fat: 30 g
  • Total Carbohydrate: 25 g
  • Protein: 22 g